Curriculum Vitae of Ryon P. Graf, PhD
Curriculum Vitae of Ryon P. Graf, PhD
Sanford Burnham Prebys Medical Discovery Institute (2014)
Degree: Ph.D. Biomedical Sciences
Specialization: Mechanisms of Cancer Metastasis
Med-Into-Grad Clinical Fellowship (Howard Hughes Medical Institute)
University of California Irvine (2008)
Degree: B.S. Genetics
Honors in Biology, Excellence in Research
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (2007)
Watson School of Biological Sciences
Undergraduate Research Program, Summer 2007
La Jolla High School, San Diego, CA (2004)
Scher HI, Graf RP, Schreiber NA, McLaughlin B, Lu D, Louw J, et al. Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer. Eur Urol. 2016.
Scher HI, Lu D, Schreiber NA, Louw J, Graf RP, Vargas HA, et al. Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer. JAMA Oncol. 2016.
McDaniel AS, Ferraldeschi R, Krupa R, Landers M, Graf RP, Louw J, et al. Phenotypic diversity of circulating tumour cells in patients with metastatic castration-resistant prostate cancer. BJU Int. 2016.
Anantharaman A, Friedlander T, Lu D, Krupa R, Premasekharan G, Hough J, Edwards M, Paz R, Lindquist K, Graf R, Jendrisak A, Louw J, Dugan L, Baird S, Wang Y, Dittamore R, Paris PL. Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients. BMC cancer 16, 744 (2016); published online EpubSep 22 (10.1186/s12885-016-2758-3).
Greene SB, Dago AE, Leitz LJ, Wang Y, Lee J, Werner SL, Patel P, Jia S, Zhang L, Tucker EK, Malchiodi M, Graf RP, Dittamore R, Marrinucci D, Landers M. Chromosomal Instability Estimation Based on Next Generation Sequencing and Single Cell Genome Wide Copy Number Variation Analysis. PloS one. 2016;11(11):e0165089.
Beltran H, Jendrisak A, Landers M, Mosquera JM, Kossai M, Louw J, Krupa R, Graf PR, et al. The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015.
Scher HI, Graf RP, Louw J, Jendrisak A, Johnson A, Greene S, et al. Single CTC characterization to identify phenotypic and genomic heterogeneity as a mechanism of resistance to AR signaling directed therapies (AR Tx) in mCRPC patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2016;34:suppl 2S; abstr 163. (Selected for oral abstract presentation at ASCO GU 2016)
Lu D, Graf RP, Harvey M, Madan RA, Heery C, Marte J, et al. Detection and Characterization of Circulating Tumour Cells from Frozen Peripheral Blood Mononuclear Cells. Journal of Circulating Biomarkers. 2015.
Werner SL, Graf RP, Landers ML, Valenta DT, Schroeder M, Greene SB, et al. Analytical Validation and Capabilities of the Epic CTC Platform: Enrichment-Free Circulating Tumour Cell Detection and Characterization. Journal of Circulating Biomarkers. 2015;4(3).
Graf R, Keller N, Barbero S, Stupack D. Caspase-8 as a Regulator of Tumor Cell Motility. Current molecular medicine. 2014 Jan 27. PubMed PMID: 24467204. Epub 2014/01/29.
Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, et al. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adhesion & Migration. 2013 Jun 10;7(4). PubMed PMID: 23751956. Epub 2013/06/12.
Shanique A. Young, Ryon Graf and Dwayne G. Stupack (2013). Neuroblastoma Integrins, Neuroblastoma, Prof. Hiroyuki Shimada (Ed.), ISBN: 978-953-51-1128-3, InTech, DOI: 10.5772/55991. Available from:http://www.intechopen.com/books/neuroblastoma/neuroblastoma-integrins
Mielgo A, Torres VA, Schmid MC, Graf R, Zeitlin SG, Lee P, et al. The death effector domains of caspase-8 induce terminal differentiation. PloS one. 2009;4(11):e7879. PubMed PMID: 19924290. Pubmed Central PMCID: PMC2774162. Epub 2009/11/20.
Other Scientific Writing
Science Blog: RyonGraf.com (~500 viewers per month)
Cancer Q&A Blog: Articles for cancer education based on questions submitted by readers. (1/2011 – 1/2012) Research and Trends Blog: Developments in research, biotechnology, cancer therapy, and clinical trials. (1/2012 – present) Over 80 articles and posts to date.
New University Newspaper, UC Irvine (Circulation: 10,000)
Staff Science Writer, contributed regular columns on topical issues. (2005 – 2008)
Awards and Honors
HHMI Med-Into-Grad Fellowship, Cancer (2013)
The Med-into-Grad Initiative provides doctoral students with exposure to unmet needs in diagnostics and therapeutics through clinical immersion. Funded by the Howard Hughes Medical Research Institute and hosted by the UC San Diego School of Medicine.
Michael and Judy Leon Award (2008)
Scholarship awarded one graduating senior at UC Irvine (seeking to pursue Ph.D. studies and a career in science). 1st ever recipient.
Excellence in Research (2008)
Receipt of distinction of Excellence in Research in Biological Sciences at UC Irvine. Completion of undergraduate honors thesis research project, paper, talk, and poster presentation.
Florence Riford Scholarship (awarded four consecutive cycles: 2004 – 2007)
Merit Scholarship Awarded by Rotary Club of La Jolla for pursuit of a Bachelor’s of Science in Biology, the physical sciences, or engineering.
Service Above Self, La Jolla Rotary Foundation Award (2007)
Merit award secondary to Scholarship.
Cold Spring Harbor Laboratory Undergraduate Research Program (2007)
One of 28 accepted from over 800 applicants globally.
Sloan-Kettering Summer Undergraduate Research Program (2007, declined)
Undergraduate research program at Gerstner Sloan-Kettering Comprehensive Cancer Center (conflict with CSHL above).
Dean’s Honor List, Biological Sciences, UC Irvine (awarded seven times: 2004 – 2008)
Research Mentorship (July 2008 – January 2014)
Provided one-on-one instruction of undergraduates and high school students in laboratory techniques, project design, scientific etiquette, ethics, and methods.
Students mentored at least 20 hours:
Robert Yuan UCSD 2011
Mary Rose Pascua (Amgen Scholars 2008) Loyola Marymount 2010
Nick Johnson (Scripps Ranch High Honors Internship) UCSD 2013
Jenna Kastenschmidt (Amgen Scholars 2009) MNSU 2010
William Price (Amgen Scholars 2010) Southern Oregon 2011
Phillip Murray (Amgen Scholars 2010) CU Boulder 2011
Jesse Liang (Scripps Ranch High Honors Internship) UCLA 2014
Sasha Azar UCSD 2011
Lindsay Oosterhouse UCSD 2014
Nicolas Etcheverry UCSD 2014
Bishop’s School Scientific Outreach (2008)
Guest lectures and Cancer Center tours for Honors Biotechnology
course at the Bishop’s School in La Jolla, CA.